Middle-aged (35-54 years old) may be commonly affected, but some studies found no association of globus prevalence with age (Tang et al 2016).Women may be affected more often (reported in some studies in a 2:1 ratio compared to males), however some studies find no difference in incidence between sexes (Selleslagh et al.4-5% of all ENT outpatient referrals are due to globus sensation (Moloy et al.Globus is managed in 6.7 per 100,000 encounters in primary care (Pollack et al 2013).46% have at one point in their life "felt like a lump is in their throat" (Interview of 147 healthy individuals in United Kingdom, not using Rome III criteria- Thompson et al.
21.5% overall lifetime prevalence of globus syndrome (Survey of >3,000 participants in China using Rome III criteria- Tang et al.6.0% prevalence of globus feeling for >3 months (Survey of 1,158 women from general population in United Kingdom, not using Rome III criteria- Dreary et al 1995).3.5% prevalence of globus syndrome (Cross-sectional study of 995 young, healthy Iranians assessed using the Rome III diagnostic criteria for functional GI disorders- Adibi et al 2012) ( see below EVALUATION: Rome IV Diagnostic Criteria for Globus Syndrome).Prevalence: Ranges from 3.5% to 46% depending on the population and diagnostic criteria.He is also responsible for elucidating gastroesophageal reflux as a possible etiology for globus. Malcomson coins the more accurate term "globus pharyngeus" as he showed most patients with globus did not have a hysterical personality nor mostly female. He described globus as a result of increased pressure on the thyroid cartilage due to contraction of neck strap muscles. 1707: John Purcell coins the term "globus hystericus" as he attributed globus to "hysteric fits".The term "globus" is Latin for "ball" (Harrar et al 2004) ~486 BCE: Hippocrates first described globus sensation (lump in throat), believed to be limited to women due to the proposed link between hysteria and uterine dysfunction.Symptoms may improve with eating or swallowing (Aziz et al. This functional disorder not associated with dysphagia, odynophagia or reflux, though the globus sensation itself may co-occur with these symptoms. Globus syndrome is a diagnosis of exclusion that requires the absence of structural, histopathological (mucosal), or esophageal motility abnormalities. Definition: Globus Syndrome-A functional esophageal disorder characterized by an intermittent or constant, non-painful sensation of fullness or lump/foreign body in the throat ("globus" is Latin for "ball").
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